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Refinement and validation of a comprehensive clinical diagnostic model (GAMAD) based on gender, age, multitarget circulating tumour DNA methylation signature and commonly used serological biomarkers for early detection of hepatocellular carcinoma: a multicentre, prospective observational study protocol

tech

Introduction Prompt detection of hepatocellular carcinoma (HCC) in patients with chronic liver diseases is critical for enhancing prognosis. Existing imaging techniques and serum markers fall short of clinical needs. This study aims to establish a non-invasive diagnostic model for early HCC detection in the Chinese population. Methods and analysis This prospective, multicentre, observational study will enrol 2000 participants, including HCC patients, those with chronic liver diseases (hepatitis, cirrhosis and benign liver space-occupying lesions), and healthy individuals. The study will collect demographic data and blood samples, which will be used to test α-fetoprotein (AFP), des--carboxy-prothrombin (DCP) and circulating tumour DNA (ctDNA) methylation.

BMJ     Sep 20, 2023

Urban climate research project helps shape minority students ... - Argonne National Laboratory

A rooftop in Chicago seems like an unlikely place to start a science career, but on a sunny morning in May, several Northeastern Illinois University (Northeastern) students gathered on the top of a campus building. They were accompanied by scientists from the U.S. Department of Energy’s (DOE) Argonne National Laboratory and Northeastern faculty as they installed scientific instruments capable of measuring wind, temperature, rainfall, snow accumulation, radiation and air pollution.

anl.gov     Sep 19, 2023