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What takes 4 years to make and costs $20K? A San Francisco trash can

That costly, boxy bin is among six trash cans hitting San Francisco’s streets this summer in the city’s long saga in search of the perfect can. Overflowing trash cans are a common sight in the Northern California city, along with piles of used clothes, shoes, furniture and other items strewn about on sometimes-impassable sidewalks.
— (Fortune) (August 13)   (Pocket)

What If Cells Kept Receipts of Their Gene Expression?

At first glance, an Escherichia Coli (E. Coli) bacterium looks a bit like a Cheeto, with the same puffy cylindrical shape. But it is a Cheeto lookalike with incredible immune defenses. Behind the bacteria’s unassuming exterior are complex systems that help protect it from attacks by foreign invaders. For Seth Shipman, a bioengineer at the University of California, San Francisco, leveraging these defenses has opened new technological possibilities for recording gene expression in cells. “We’re taking a bunch of bacterial parts and repurposing them for biotechnology that they weren’t intended to be used for,” he says.
— (Wired) (August 12)   (Pocket)

Are San Francisco's NIMBYs Finally Getting Their Comeuppance?

San Francisco's homegrown hostility to new development has made it the epicenter of California's housing crisis. It will now become a testing ground for a newly empowered state government's ability to force liberalizing reforms on a city that repeatedly refuses to build.
— (Reason) (August 11)   (Pocket)

Veracyte Q2 Revenues up 32 Percent, Beat Analyst Expectations

For the three months ended June 30, the South San Francisco, California-based molecular diagnostics company reported total revenues of $72.9 million compared to $55.1 million in the same period of 2021. Q2 revenues came in well ahead of analysts' average expectation of $68.0 million.
— (Genome Web) (August 3)   (Pocket)

The gap between monkeypox vaccine demand and supply is dire in hotspot cities

In some states that have become hotspots for the monkeypox outbreak, there's a drastic disconnect between the number of doses that local health officials say they need versus what they have been allotted, an Axios Local review of a dozen states found. Why it matters: Across the nation, health officials worry that the outbreak could become the country's second major public health disaster in as many years if we don't work faster to contain it.What they’re saying: "It is something that we could contain, but it's gonna require a great deal of effort. I believe we're behind,” says Georges Benjamin, who leads the American Public Health Association.
— (Axios) (August 2)   (Pocket)

Twitter Censors All Content From The Epoch Times

Twitter Censors All Content From The Epoch Times Authored by Eva Fu via The Epoch Times, Twitter has imposed a blockade on all content from The Epoch Times without explanation, raising further concerns about freedom of speech on the platform. The Twitter logo is seen on a sign at the company's headquarters in San Francisco, California on Nov. 4, 2016. (Josh Edelson/AFP via Getty Images) Beginning on the evening of July 28, the platform put up a warning on all links from The Epoch Times. A click on a link would direct users to a page titled “Warning: this link may be unsafe” which prompts users to return to the previous page.
— (ZeroHedge Opinion) (July 29)   (Pocket)

What If Cells Kept Receipts of Their Gene Expression?

At first glance, an Escherichia Coli (E. Coli) bacterium looks a bit like a Cheeto, with the same puffy cylindrical shape. But it is a Cheeto lookalike with incredible immune defenses. Behind the bacteria’s unassuming exterior are complex systems that help protect it from attacks by foreign invaders. For Seth Shipman, a bioengineer at the University of California, San Francisco, leveraging these defenses has opened new technological possibilities for recording gene expression in cells. “We’re taking a bunch of bacterial parts and repurposing them for biotechnology that they weren’t intended to be used for,” he says.
— (Wired) (August 12)   (Pocket)

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

A Stanford University team presents a plant root reprogramming strategy that relies on synthetic transcriptional regulator-based genetic circuits for a paper in Science. By controlling gene expression in specific root cell types with synthetic DNA delivered with Agrobacterium tumefaciens bacteria, the researchers put together more than 1,000 genetic circuits, including circuits that successfully tweaked root gene expression and related root features in the Nicotiana benthamiana plant model — a strategy that may ultimately help plants respond to environmental stressors such as climate change. The study's authors caution that "[r]eprogramming crops using synthetic genetic circuits will require careful tuning." Even so, they suggest that "methods for programming novel traits in plants will become increasingly useful as climate challenges ...
— (Genome Web) (August 12)   (Pocket)

Isoform Function Prediction Using Deep Neural Network. (arXiv:2208.03325v1 [q-bio.GN])

Isoforms are mRNAs produced from the same gene site in the phenomenon called Alternative Splicing. Studies have shown that more than 95% of human multi-exon genes have undergone alternative splicing. Although there are few changes in mRNA sequence, They may have a systematic effect on cell function and regulation. It is widely reported that isoforms of a gene have distinct or even contrasting functions. Most studies have shown that alternative splicing plays a significant role in human health and disease. Despite the wide range of gene function studies, there is little information about isoforms' functionalities. Recently, some computational methods based on Multiple Instance Learning have been proposed to predict isoform function using gene function and gene expression ...
— (arXiv) (August 9)   (Pocket)