✅   Determination of silver(I)-binding sites in canonical B-DNA by NMR spectroscopy

science

The interaction of metal ions with nucleic acids was studied by determining the initial binding sites of Ag^(+) ions at unmodified B-DNA by NMR spectroscopy. In particular, NMR spectra were recorded of the Dickerson-Drew dodecamer sequence in the presence of different ratios of Ag^(+) ions to DNA. The data indicate that the coordination of the first three Ag^(+) ions per duplex preferentially takes place inside the B-DNA helix rather than at other possible binding sites such as the negatively...

NCBI     May 02, 2025