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Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis

science

An important question in organogenesis is how tissue-specific transcription factors interact with signaling pathways. In some cases, transcription factors define the context for how signaling pathways elicit tissue- or cell-specific responses, and in others, they influence signaling through transcriptional regulation of signaling components or accessory factors. We previously showed that during optic vesicle patterning, the Lim-homeodomain transcription factor Lhx2 has a contextual role by linking the Sonic Hedgehog (Shh) pathway to downstream targets without regulating the pathway itself. Here, we show that during early retinal neurogenesis in mice, Lhx2 is a multilevel regulator of Shh signaling. Specifically, Lhx2 acts cell autonomously to control the expression of pathway genes required for efficient activation and maintenance ...
NCBI     Dec 03, 2022

Wound Care Biologics Market Growth & Opportunities 2022-2028 | Smith & Nephew Plc., Organogenesis, Inc., Integra Lifesciences Holdings Corporation, Skye Biologics, - Digital Journal

The Wound Care Biologics Market research meticulously dissects all of the market participants, regions, types, and operations. The investigation involves a thorough evaluation of growth elements, Market delineations, manufacturers, Market eventuality, and significant trends in order to appreciate future demand and assiduity prognosis. The exploration study covers significant Market competitors, CAGR figures, Market instigation, limitations, and competitive strategies used extensively in the region. The investigation also includes a thorough examination of the Wound Care Biologics Market, taking into consideration all factors that affect growth. It employs SWOT analysis.
digitaljournal.com     Nov 20, 2022