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Cross-sectional study investigating the association between inflammatory biomarkers and neuropathy in adolescents with type 1 diabetes

tech

Objectives The aims of this study were to investigate circulating levels of inflammatory markers in adolescents with type 1 diabetes with and without different types of neuropathies and evaluate the association between inflammatory biomarkers, nerve function and clinical parameters. Design Cross-sectional study. Setting Hospitals and Steno Diabetes Center in Denmark. Participants Adolescents with more than 5 years of diabetes duration were investigated for large fibre, small fibre and autonomic neuropathy as a part of the T1DANES study. Blood samples from the participants were analysed for inflammatory biomarkers by Meso Scale Discovery multiplexing technology. Primary and secondary outcome measures Inflammatory biomarkers and results of diagnostic nerve tests.

BMJ     Oct 07, 2023