Become A Wiser, More Profitable Trader

✅   Exploring Mycobacterium tuberculosis rRNA Transcriptomic Signatures asResponse to Anti-TB Treatment in Whole Blood RNA-seq Data

science

Current clinical tools for monitoring tuberculosis (TB) treatment response rely mostly on sputum culture and chest X-ray, which are unreliable in patients with low bacterial loads and lack the desirable promptness. There is a need for biomarkers able to provide earlier and more accurate insights into pathogen viability and response to therapy. We analyzed publicly available whole-blood RNA-seq data from 79 TB patients sampled at diagnosis, and weeks 1, 4, and 24 of standard anti-TB treatment. After aligning human reads and filtering, remaining reads were mapped to the Mycobacterium tuberculosis H37Rv genome to quantify rRNA subunit transcripts (16S, 23S, 5S, ITS1, ITS2).

BioRxiv     Jun 20, 2025