United States   Tech   Markets   Politics   Business   Science   Memes  









What are the challenges in targeting G-quadruplex structures for therapy? 




Sort By:                     

✅   Opportunities and challenges with G-quadruplexes as promising targets for drug design

science

INTRODUCTION: G-quadruplexes (G4s) are secondary structures formed in guanine-rich regions of nucleic acids (both DNA and RNA). G4s are significantly enriched at regulatory genomic regions and are associated with important biological processes ranging from telomere homeostasis and genome instability to transcription and translation. Importantly, G4s are related to health and diseases such as cancer, neurological diseases, as well as infections with viruses and microbial pathogens. Increasing...

NCBI     Sep 18, 2024