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✅   Possible reluctance to shorten antibiotic duration in Gram-negative bacteremia and limitations of mortality-based outcomes: the need to prioritize clinical-microbiologic recurrence in future trials-Insights from the "Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness" (BALANCE) Trial

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Shorter antibiotic durations (≤7 days) have demonstrated non-inferiority to longer courses for several bacterial infections, but evidence for bacteremia remains limited. Trials often exclude patients with bacteremia, focus on uncomplicated cases, or lack sufficient power to detect clinically significant effects. The recent Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness (BALANCE) trial, a multicenter study spanning 74 hospitals, investigated 7 versus 14 days of antibiotic...

NCBI     Apr 16, 2025