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Researchers develop gene therapy that can target airway and lungs via nasal spray

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For gene therapy to work well, therapeutic molecules need to be efficiently delivered to the correct locations in the body -- a job commonly given to adeno-associated viruses (AAV). To improve the AAV's ability to deliver therapeutics specifically to the lungs and airway, researchers developed and applied a new version, called AAV.CPP.16, that can be administered with a nasal spray. In preclinical models, the innovative tool outperformed previous versions by more effectively targeting the airway and lungs and showing promise for respiratory and lung gene therapy.

Science Daily     May 22, 2025