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Bias toward a mechanistic VAT-centric interpretation of MASLD, heavily relying on transcriptomic data and heritability attribution, which may overstate causality and generalizability while acknowledging SAT attenuation.
Single-nucleus RNA sequencing of adipose tissue suggests decreased VAT adipocyte differentiation in MASLD, with VAT gene-set variants accounting for 17% of MASLD heritability and overlapping with MASLD adipocyte gene expression; SAT shows attenuated effects.
Limitations: training data may underrepresent niche biomedical biases; cautious.
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