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✅   Effects of S-ketamine on recovery quality in elderly patients with impaired intrinsic capacity after total knee arthroplasty: a single-centre, randomised, double-blind, placebo-controlled study protocol

Health

Introduction Elderly patients with impaired intrinsic capacity are at increased risk for delayed or suboptimal recovery from surgery. S-ketamine has been proven to improve postoperative recovery quality. However, limited trials are studying the postoperative recovery quality in elderly patients with impaired intrinsic capacity. Therefore, the objective of this study was to evaluate the impact of S-ketamine on the quality of recovery in elderly patients with impaired intrinsic capacity following total knee arthroplasty. Methods and analysis This is a single-centre, randomised, double-blind, placebo-controlled trial. Participants undergoing total knee arthroplasty will be randomly assigned in a 1:1 ratio to either the S-ketamine group (n=80) or the placebo group (n=80).

BMJ     Apr 28, 2025