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✅   Incidence of major adverse kidney events after ICU admission in COVID-19 and non-COVID-19 ARDS patients

Health

Objectives To compare the incidence and drivers of major adverse kidney events (MAKEs) between COVID-19 and non-COVID-19 acute respiratory distress syndrome (ARDS) patients, with a focus on long-term kidney outcomes. Design Retrospective cohort study. Setting Single-centre intensive care unit in the Midlands, UK. Participants 708 ARDS patients (458 COVID-19, 250 non-COVID-19). Primary and secondary outcome measures The primary outcome was MAKE at 365 days (MAKE-365), defined as new renal replacement therapy (RRT), estimated glomerular filtration rate (eGFR) <75% of baseline or all-cause mortality. Secondary analyses examined non-mortality MAKE components. Results The incidence of MAKE-365 was significantly higher in the non-COVID-19 group compared with the COVID-19 group (66% vs 39%, p<0.001), primarily driven ...

BMJ     May 07, 2025