Learning and memory problems in down syndrome linked to alterations in genome's 'dark matter'

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The activity of Snhg11, a gene found in the 'dark matter' of the genome, is critical for the function and formation of neurons in the hippocampus, specifically in an area critical for learning and memory. Researchers have discovered the gene is less active in brains with three copies of chromosome 21, which causes Down syndrome, potentially contributing to the condition's intellectual disabilities. The researchers plan on carrying out further research to discover the exact mechanisms of action involved, information that could open potential avenues for new therapeutic interventions.

Science Daily     Feb 27, 2024