Gene expression impacts brain aging  on May 20, 2024


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✅ Dynamic changes in mitochondria support phenotypic flexibility of microglia

science

The ability of microglia to sense the environment and alter their cellular phenotype according to local neuron and tissue needs is a hallmark feature of these cells. Numerous receptors that comprise the microglial "sensome" have been identified, but how microglia interpret combined signaling from diverse receptors and adjust multiple cellular attributes in a coordinated fashion is not well understood. Mitochondria are increasingly recognized as essential signaling hubs, and these organelles can regulate coordinated remodeling of cell attributes in immune cells, including macrophages. Given these findings, surprisingly little is known about microglial mitochondria in vivo and how the state of these organelles may impact microglial attributes and functions.

BioRxiv     May 20, 2024