Multiple-breakthroughs-in-cancer-research-and-treatment-development  on January 19, 2024


Balanced News   View All Sources

Exploring new frontiers: Organoids in cancer research - Scientist Live

In 2009, Sato et al. described the ability to indefinitely culture 3D organoids in Corning® Matrigel® matrix for organoid culture (Corning Inc., US) from single Lgr5-positive intestinal stem cells under defined culture conditions that artificially provide niche factors (e.g., R-spondin, noggin, epidermal growth factors). Intestinal organoids were successfully established, and the next 5 years saw the establishment of numerous organoid culture protocols, such as for the colon and small intestine, retina, brain, liver, stomach, and breast. In 2014, the research of Gao et al. and Li et al.9 let to breakthroughs for using organoid models in cancer research. The researchers performed comprehensive genomic analysis, which showed that the organoids closely recapitulated in vivo prostate cancers in copy-number ...

scientistlive.com     Jan 19, 2024