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✅   Perceptions of chemoprevention among individuals at high risk of oral cancer: qualitative study within the UK-based SAVER trial

Science

Objectives Clinical trials are needed to advance interventions such as chemoprevention that have potential to reduce the risk of malignant transformation in individuals with oral potentially malignant disorders. We explored the perspectives of those screened or invited to join an early phase clinical trial (the SAVER trial: Sodium valproate for the epigenetic reprogramming of high-risk oral epithelial dysplasia). Our objectives were to inform the SAVER trial while it was ongoing and to provide insights for future trials and chemoprevention therapy development more broadly. Design Qualitative study involving audio-recorded, semistructured interviews. Analysis of transcribed interviews drew on thematic approaches. Setting Five UK-based sites involved in SAVER.

BMJ     Jun 17, 2025