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✅ Pooling of primary care electronic health record (EHR) data on Huntingtons disease (HD) and cancer: establishing comparability of two large UK databases

Objectives To explore whether UK primary care databases arising from two different software systems can be feasibly combined, by comparing rates of Huntington’s disease (HD, which is rare) and 14 common cancers in the two databases, as well as characteristics of people with these conditions. Design Descriptive study. Setting Primary care electronic health records from Clinical Practice Research Datalink (CPRD) GOLD and CPRD Aurum databases, with linked hospital admission and death registration data. Participants 4986 patients with HD and 1 294 819 with an incident cancer between 1990 and 2019. Primary and secondary outcome measures Incidence and prevalence of HD by calendar period, age group and region, and annual age-standardised incidence of 14 ...

BMJ     Feb 15, 2024