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Reporting of surrogate endpoints in randomised controlled trial reports (CONSORT-Surrogate): extension checklist with explanation and elaboration

Science

Evidence from well designed, conducted, and reported randomised controlled trials (referred to as trials in this article) assessing the effect of an intervention on the target outcome of interest (eg, all cause mortality) are required to determine the efficacy or effectiveness of interventions.1 Inadequate reporting of trials reduces their usefulness for decision making and, thus, contributes to the rising problem of research waste.23 Using reporting guidelines has been shown to be successful in improving the usefulness of trial evidence and reduce research waste.3 The CONSORT (Consolidated Standards of Reporting Trials) statement is a 25 item checklist widely used for the reporting of parallel group trial reports.4 While the CONSORT checklist has improved the completeness of trial reports,5 ...

BMJ     Jul 09, 2024